S7451

SJ-172550

≥95% (HPLC)

• Synonym(s): 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester
• Empirical Formula (Hill Notation): C₂₂H₂₁N₂O₅Cl
• CAS Number: 431979-47-4
• Molecular Weight: 428.87
• MDL number: MFCD03142926
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824584
• NACRES: NA.77

Properties

• assay: ≥95% (HPLC)
• form: powder
• color: orange
• solubility: DMSO: ≥30 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCOc1cc(cc(Cl)c1OCC(=O)OC)\C=C2\C(C)=NN(C2=O)c3ccccc3
• InChI: 1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10-
• InChI key: RKKFQJXGAQWHBZ-YVLHZVERSA-N

Description

Application

SJ-172550 may be used in MDMX and p53-mediated cell signaling studies.

Biochem/physiol Actions

SJ-17255 is a MDMX inhibitor.

SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable