This product contains a mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum, and the molecular weights and distribution of this mixture have not been characterized. Although not tested for batch release, this compound is known to dissolve in DMSO at least up to a concentration of 20 mM, as referenced in Cellular Signalling 84 (2021): 110023.
S0292
Silymarin
flavonolignans
Synonym(s):
flavolignans
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10 G
$62.20
50 G
$166.50
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10 G
$62.20
50 G
$166.50
About This Item
Recommended Products
biological source
plant (Silybum marianum)
Quality Level
form
powder
technique(s)
toxicology assay: suitable
application(s)
microbiology
storage temp.
−20°C
SMILES string
O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI key
SEBFKMXJBCUCAI-UHFFFAOYSA-N
General description
Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.[1]
Application
Biochem/physiol Actions
Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.[1]
Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.
Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin. [4]
Other Notes
Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Customers Also Viewed
Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
Sozmen M, et al.
Journal of Veterinary Science, 15(1), 51-60 (2012)
Nuriye Ezgi Bektur Aykanat et al.
Pharmacological reports : PR, 72(1), 199-207 (2020-02-06)
14 million people are diagnosed with new cancer and approximately 8 million people die from cancer every year. Hepatocellular carcinoma is the most common type of liver cancer and covers almost 5-6% of cancer deaths worldwide. Silybum marianum, a plant
Multitargeted therapy of cancer by silymarin
Ramasamy K and Agarwal R
Cancer letters, 269(2), 352-362 (2008)
Chun-Ping Lu et al.
Chemico-biological interactions, 290, 12-18 (2018-05-14)
Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/Ins.cre
Vieri Piazzini et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Two novel nanomicellar formulations were developed to improve the poor aqueous solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and mixed nanomicelles combining Soluplus with d-α-tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS) were prepared using
Articles
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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WHAT IS THE MOLECULAR WEIGHT? cAN i DISSOLVE IT IN dmso, i WANT TO USE IT IN CELL LINES?
1 answer-
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This silymarine.....is it isomer of Silybinin A and B
1 answer-
This product is a fairly crude extract from Milk Thistle consisting of a number of components. The minimum purity specification for this material is 30%. Within that fraction there is a mixture of isomers. The amount of each has not been quanitified, however the literature suggests that these are present in the plant at equimolar ratios. Please see the link below to review a sample or lot specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/s0292#product-documentationHelpful?
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How much purity is there in this product?
1 answer-
This product is at least 30% Silymarin. The impurities have not been fully characterized. However, other Milk Thistle flavonolignans are expected to be present. These include dehydrosilybin, desoxysilycristin, desoxysilydianin, silandrin, silybinome, silyhermin, and neosilyhermin. In addition, apigenin, silybonol, as well as myristic, palmitic, stearic, and oleic acids have also been reported.
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I want to give it orally to a mouse. How should I prepare it?
1 answer-
This product has not been tested for in vivo or in vitro use. The solubility of this compound is tested at 10 mg/mL in ethanol, which may not be ideal for animal models. There are numerous published papers noting oral administration in mice.
See the links below to review examples:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156955/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622766/Please note that unless otherwise stated, this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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how can we dissolve silymarin ( in vitro study )
1 answer-
The solubility of this material is tested at a concentration of 50 mg per 5 mL of ethanol, giving a clear to slightly hazy appearance.
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