PHL89281

Silychristin

phyproof^® Reference Substance

• Synonym(s): Silymarin II
• Empirical Formula (Hill Notation): C₂₅H₂₂O₁₀
• CAS Number: 33889-69-9
• Molecular Weight: 482.44
• MDL number: MFCD00883715
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• assay: ≥95.0% (HPLC)
• manufacturer/tradename: PhytoLab
• application(s): food and beverages
• format: neat
• storage temp.: 2-8°C
• SMILES string: COc1cc(ccc1O)[C@@H]2Oc3c(O)cc(cc3[C@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O
• InChI: 1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1
• InChI key: BMLIIPOXVWESJG-LMBCONBSSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Application

• Unveiling the healing properties of 2,3-dehydrosilychristin: A silymarin-derived flavonolignan with potent pharmacological activities, highlighting its significance in mitigating oxidative stress and enhancing cellular repair mechanisms in liver tissues (Tripathi et al., 2024).


• Application of SNAP-tag-EGFR cell membrane chromatography model: This study identifies Silychristin as a key antitumor agent in Silybum marianum, detailing its role in targeted cancer therapies and its efficacy in inhibiting tumor cell proliferation (Zhang et al., 2024).


• Pharmaceutical prospects of Silymarin for neurological patients: Provides an update on the neuroprotective properties of Silychristin, emphasizing its therapeutic potential in treating neurological disorders through modulation of oxidative stress and inflammation (Ranjan and Gautam, 2023).


• Structural basis of Nrf2 activation by flavonolignans: Explores how Silychristin, as part of the Silymarin complex, activates the Nrf2 pathway, offering insights into its application in enhancing antioxidant responses at the molecular level (Bello, 2023).


• Mechanistic Insights into the Pharmacological Significance of Silymarin: Reviews the broad pharmacological actions of Silychristin within the Silymarin complex, discussing its anti-inflammatory, antioxidant, and antifibrotic roles, which are pivotal for comprehensive healthcare applications (Wadhwa et al., 2022).

Other Notes

This compound is commonly found in plants of the genus: silybum

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable