Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

PZ0389

Sigma-Aldrich

PF-06869206

≥98% (HPLC)

Synonym(s):

(S)-3-Chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile, PF 06869206, PF06869206

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$89.30
25 MG
$419.00

$89.30

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$89.30
25 MG
$419.00

About This Item

Empirical Formula (Hill Notation):
C15H14ClF3N4O2
CAS Number:
2227425-05-8
Molecular Weight:
374.75
UNSPSC Code:
51111800
NACRES:
NA.77

$89.30

Check Cart for Availability
Request a Bulk Order

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

ClC1=C(C)NC2=C1N=C(C(F)(F)F)C(C#N)=C2N3C[C@@H](CO)OCC3

InChI

1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1

InChI key

ATFQBBCQZKVZJN-QMMMGPOBSA-N

Application

PF-06869206 has been used to selectively inhibit the activity of sodium-phosphate cotransporter 2a (NaPi2a).[1]

Biochem/physiol Actions

PF-06869206 is a selective inhibitor against sodium-phosphate cotransporter 2A (NaPi-2a, NaPi-Iia, Na+/Pi cotransporter 2A, Na+-dependent phosphate cotransporter 2A).
PF-06869206 may be used to treat patients with mineral and hormonal derangements linked with increased cardiovascular risk in chronic kidney disease. This drug might also improve urinary phosphate excretion.[2] PF-06869206 has an ability to decrease phosphate uptake in human embryonic kidney (HEK) cells transfected with mouse or rat renal sodium-dependent phosphate transporter genes (Npt2a).[3]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthesis of PF-06869206
Kocienski P
Synfacts, 14(07), 0675-0675 (2018)
Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)
Filipski KJ, et al.
ACS Medicinal Chemistry Letters, 9(5), 440-445 (2018)
In vivo effects of renal Npt2a inhibition
Thomas L, et al.
Faseb Journal, 33(1-supplement), 751-752 (2019)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service