The epitope recognized by PLA0161 maps to a region between residue 1 and 50 of human males absent on the first (MYST histone acetyltransferase 1) using the numbering given in entry BAB13924.1 (GeneID 84148).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
MOF is a member of the MYST family of histone acetyltransferases (HAT). MOF has been shown to be required for histone H4 lysine K16-specific acetylation. MOF interacts with ATM (ataxia-telangiectasia-mutated) and may participate in the activation of ATM in response to DNA damage.
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Hutchinson-Gilford Progeria syndrome (HGPS) is a lethal premature aging disorder caused by a de novo heterozygous mutation that leads to the accumulation of a splicing isoform of Lamin A termed progerin. Progerin expression deregulates the organization of the nuclear lamina
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