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P1618

Sigma-Aldrich

Protein Phosphatase 2Ac from bovine kidney

buffered aqueous glycerol solution

Synonym(s):

PP2Ac

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

bovine kidney

Quality Level

200

assay

≥90% (SDS-GE)

form

buffered aqueous glycerol solution

specific activity

~2 U/vial

mol wt

36 kDa

UniProt accession no.

P67774

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

bovine ... PPP2CA(282320)

General description

Protein phosphatase 2 catalytic subunit a (PPP2CA/PP2Ac) gene is mapped to human chromosome 5q31.1.[1] The PPP2CA gene encodes the catalytic subunit of PP2A (protein phosphatase 2), a serine/threonine phosphatase.[2]

Biochem/physiol Actions

Divalent cation-independent catalytic subunit of protein phosphatase 2A. Useful for functional studies of the A and B subunit of the phosphatase.
Protein phosphatase 2 catalytic subunit α (PPP2CA/PP2Ac) is a tumor suppressor and negatively regulates cell cycle.[3] It mainly regulates PI3K (phosphatidylinositol 3-kinase)/AKT (RAC-α serine/threonine-protein kinase) pathway, MEK1 (MAPK/ERK kinase 1), ERK (extracellular signal-regulated kinase) family kinases and c-myc transcription factors.[4]

Physical form

1 μg per vial in 50 μl of 50 mM Tris-HCl, pH 7.0, containing 14 mM β-Mercaptoethanol, 1mM benzamidine, 0.1 mM PMSF, 1mM EDTA, and 50% glycerol.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBZ0896
SLBW4190
SLBG4354
SLBD9109
039K1218

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MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
Du H, et al.
PLoS ONE null
Myelodysplastic syndromes: an update on molecular pathology
Tormo M, et al.
Clinical And Translational Oncology, 652-61 null
Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.
Liu H, et al.
Oncotarget, 14913-25 null
Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma
Gordon IK, et al.
Molecular Cancer Therapeutics, 1540-1547 null

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