The product specification does not include a base pair length, and it is not determined in quality control testing. The best estimate is that the polymer is a mixture of different lengths ranging from 150 base pairs to 2,000 base pairs. Users requiring more specificity of the base pair lengths may need to determine it using gel electrophoresis.
P1537
Polyadenylic acid-Polyuridylic acid sodium salt
double-stranded homopolymer
Synonym(s):
Poly[A]•Poly[U]
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10 MG
$146.00
About This Item
Recommended Products
Quality Level
form
powder
Storage temp.
−20°C
SMILES string
[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)N)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=O)NC2=O)(O)O
InChI
1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
Inchi Key
VGQHQOKIMNKUEF-ZLOOHWKQSA-N
Application
Polyadenylic acid-Polyuridylic acid (polyAU) is a double stranded homodimer studied for potential therapeutic activity, especially when coupled with radiotherapy. PolyA/U is used in comparative physiochemical studies with other duplex and single-stranded polymers such as poly-A and poly-U.
Other Notes
Double stranded homopolymer
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Laplanche et al.
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With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone
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Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I, and melanoma differentiation-associated antigen 5 (RIG-I/MDA-5) helicases are known to sense double-stranded RNA (dsRNA) virus and initiate antiviral responses, such as production of type-I interferons (IFNs). Recognition of dsRNA by TLR3 or
A A Ghazaryan et al.
Journal of biomolecular structure & dynamics, 24(1), 67-74 (2006-06-20)
We employed UV light absorption and circular dichroism (CD) spectroscopic measurements to study the binding of novel water-soluble porphyrins meso-tetra-(4N-allylpyridyl)porphyrin [TAlPyP4], and its Ag containing derivative to the poly(rA)poly(rU) and poly(rI)poly(rC) RNA duplexes. Our results suggest that TAlPyP4 associate with
Frédy Barneche et al.
The EMBO journal, 25(24), 5907-5918 (2006-12-02)
Plastid translational control depends to a large extent on the light conditions, and is presumably mediated by nucleus-encoded proteins acting on organelle gene expression. However, the molecular mechanisms of light signalling involved in translation are still poorly understood. We investigated
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What is the average base pair length for this product
1 answer-
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I'd like to know the homogeneity of this product, or at least the % A:U base pairing. My application is sensitive to high mismatch and single strand RNA content and I'm hoping this is at least 85% A:U base paired.
1 answer-
Unfortunately, the homogeneity and A:U ratio are not determined for this product. The material is prepared by separately preparing polyA and polyU strands by an enzymatic method. The individual polyA and polyU strands are purified to remove low molecular weight species then annealed by heating, followed by a slow cooling process. Historical information indicates an approximate starting ratio of 1:2 molar concentration of Poly(A) to Poly(U), respectively. There is an estimated sodium content of 5 - 6%.
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