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This product is a double-stranded alternating DNA copolymer, although it is possible for single strands to be present. The sequence of each strand is an alternating sequence of dAdTdAdTdAdT….. or dATdATdATdAT… since dT (deoxythymidylic acid) and T (thymidylic acid) are the same.
P0883
Poly(deoxyadenylic-thymidylic) acid sodium salt
double-stranded alternating copolymer
Synonym(s):
Poly(dA-dT) • Poly(dA-dT)
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10 UNITS
$309.00
25 UNITS
$641.00
50 UNITS
$1,035.00
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10 UNITS
$309.00
25 UNITS
$641.00
50 UNITS
$1,035.00
About This Item
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Application
Poly(deoxyadenylic-thymidylic) (Poly(dA-dT) • Poly(dA-dT))acid is a double-stranded alternating copolymer DNA model for conformational studies of DNA structure dynamics and drug interaction.
Other Notes
Double-stranded alternating copolymer.
Unit Definition
One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).
Quantity
One mg is equivalent to ≥12 A260 units.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 25(1), 77-84 (2007-08-07)
The thermal denaturation of the synthetic high molecular weight double stranded polynucleotide poly(dA-dT) x poly(dA-dT) has been studied in aqueous buffered solution (Tris 1.0 mM; pH 7.8+/-0.2) in the presence of increasing concentrations of either Ni(2+) (borderline cation) or Cd(2+)
Marta Airoldi et al.
Chirality, 20(9), 951-960 (2008-02-05)
The thermal behavior of the synthetic, high molecular weight, double stranded polynucleotides poly(dA-dT).poly(dA-dT) [polyAT] and poly(dG-dC).poly(dG-dC) [polyGC] solubilized in the aqueous core of the quaternary water-in-oil cationic microemulsion CTAB|n-pentanol|n-hexane|water in the presence of increasing amounts of NiCl(2) at several constant
M Vorlícková et al.
Journal of biomolecular structure & dynamics, 3(1), 67-83 (1985-08-01)
The article reviews data indicating that poly(dA-dT).poly(dA-dT) is able of adopting three distinct double helical structures in solution, of which only the A form conforms to classical notions. The other two structures have dinucleotides as double helical repeats. At low
Jung Hwan Bae et al.
Cells, 8(4) (2019-04-11)
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and
Natasha McStay et al.
Nucleic acids research, 45(2), 527-540 (2016-12-03)
Herein we report the synthesis of tripodal C
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What is the sequence of Product P0883, Poly(deoxyadenylic-thymidylic) acid sodium salt?
1 answer-
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What is the difference between Poly(deoxyadenylic-thymidylic) acid sodium salt Products P0883 and P5782?
1 answer-
Prod. No. P0883 is from a different supplier than Prod. No. P5782. Chain lengths for both products can vary from batch to batch. According to information from our suppliers, the A250/A260 ratios are similar, but the A280/A260 ratio for Prod. No. P0883 will be slightly higher than that of Prod. No. P5782.
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In what should Product P0883, Poly(deoxyadenylic-thymidylic) acid sodium salt, be dissolved?
1 answer-
Per our supplier, to maintain a double stranded configuration of the polymer in solution, it should be rehydrated with a neutral buffer containing 100 mM NaCl. After reconstitution, the polymer solution should be stored at -20°C.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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