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O5632

Sigma-Aldrich

Linoleic acid, conjugated methyl ester

Synonym(s):

CLA methyl ester, Octadecadienoic acid, conjugated, methyl ester

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

plant (safflower)

assay

≥99% (GC)

form

liquid

technique(s)

GC/MS: suitable
HPLC: suitable

impurities

≤1% Linoleic acid methyl ester

functional group

carboxylic acid
ester

lipid type

omega FAs

shipped in

ambient

storage temp.

−20°C

Related Categories

General description

Conjugated linoleic acid (CLA) describes the positional and geometric isomers of C18:2 fatty acids (FA) with a conjugated double bond. cis-9, trans-11 CLA are considered as the major isomers of CLA, based on in vitro experiments and animal studies in milk.[1] The major source of CLA in human diet is the ruminant fat.[2]

Application

Linoleic acid, conjugated methyl ester (CLA) has been used as a standard for the determination of isomers of CLA in milk samples by high performance liquid chromatography (HPLC),[1] gas chromatography-mass spectrometry[3]. It has also been used in the production of sn-1,3 diacyl glycerol.[4]

Biochem/physiol Actions

Conjugated linoleic acid (CLA) isomers as supplements inhibit the growth of numerous human cancer cell lines.[3] It also possesses immunostimulant properties, prevents diabetes and reduces atherosclerosis.[4]

Other Notes

A mixture of cis- and trans-9,11- and -10,12-octadecadienoic acid methyl esters. Isomer ratio may vary from lot to lot.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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Enzymatic synthesis of structured triacylglycerols containing CLA isomers starting from sn-1, 3-diacylglycerols
Maurelli S, et al.
Journal of the American Oil Chemists' Society, 86(2), 127-133 (2009)
Examination of the persistency of milk fatty acid composition responses to fish oil and sunflower oil in the diet of dairy cows
Shingfield KJ, et al.
Journal of Dairy Science, 89(2), 714-732 (2006)
A Bougouin et al.
Journal of dairy science, 101(7), 6085-6097 (2018-04-24)
The aim of the study was to compare the effect of fiber- or starch-rich diets based on grass silage, supplemented or not with bicarbonate, on CH4 emissions and milk fatty acid (FA) profile in dairy cows. The experiment was conducted
Effect of incremental levels of sunflower-seed oil in the diet on ruminal lipid metabolism in lactating cows
Shingfield KJ, et al.
The British Journal of Nutrition, 99(5), 971-983 (2008)
Ali Karabacak et al.
TheScientificWorldJournal, 2014, 821904-821904 (2014-02-14)
This study was conducted to compare fatty acid composition and content of conjugated linoleic acid (CLA) in different regions of sheep carcasses. Lambs of the Dağlıç breed were used for this purpose. Subsequent to a 68-day period of intensive fattening

Questions

  1. What is the concentration of the product?

    1 answer
    1. This product is sold as a mixture of isomers, the molarity is not provided. This material is a mixture of cis- and trans-9,11- and -10,12-octadecadienoic acid methyl esters. The isomeric ratios will vary from lot to lot. About 42% is a mixture of cis-9,trans-11, and trans-9, cis-11 which travel as one band; trans-10,cis-12 is about 44%; cis-10,cis-12 is about 10% and the balance is about 5% of a mixture of other isomers (which includes trans-9,trans-11, etc.)

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