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Key Documents

O4011

Sigma-Aldrich

Orphanin FQ

≥95% (HPLC)

Synonym(s):

Nociceptin

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About This Item

Empirical Formula (Hill Notation):
C79H129N27O22
CAS Number:
170713-75-4
Molecular Weight:
1809.04
MDL number:
MFCD00677528
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

Q13519

storage temp.

−20°C

InChI

1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1

InChI key

PULGYDLMFSFVBL-SMFNREODSA-N

Gene Information

human ... PNOC(5368)

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Amino Acid Sequence

Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln

Biochem/physiol Actions

Endogenous agonist at opioid receptor-like1 (ORL1) receptors.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
030M1863
059K1240
088K1329
027K1576
056K1672

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C T Dooley et al.
Peptides, 21(7), 949-960 (2000-09-22)
A review of the binding studies performed on the receptor (ORL) for Orphanin FQ/Nociceptin is presented. Binding studies have been conducted using a variety of receptor sources: cell lines expressing the cloned receptor, cell lines endogenously expressing the receptor, and
R K Reinscheid et al.
Science (New York, N.Y.), 270(5237), 792-794 (1995-11-03)
A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP-binding protein (G protein)-coupled receptor (LC132) that is similar in sequence to opioid receptors. This peptide, orphanin FQ, has a primary structure reminiscent
L C Chiou
Journal of biomedical science, 7(3), 232-240 (2000-05-16)
A novel opioid receptor-like orphan receptor (ORL1) was cloned and identified to be homologous to classical opioid receptors but insensitive to traditional opioids. A heptadecapeptide, termed orphanin FQ or nociceptin (OFQ/N), was identified as its endogenous ligand. OFQ/N shares overlapping
J C Meunier et al.
Nature, 377(6549), 532-535 (1995-10-12)
The ORL1 receptor, an orphan receptor whose human and murine complementary DNAs have recently been characterized, structurally resembles opioid receptors and is negatively coupled with adenylate cyclase. ORL1 transcripts are particularly abundant in the central nervous system. Here we report

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