M8683

Anti-Matrix Metalloproteinase-7, N-Terminal of Catalytic Zinc Site antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-MMP-7
• MDL number: MFCD02096854
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen (active form) 18 kDa (reduced); antigen (pro-form) 28 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1:1,000
• UniProt accession no.: P09237
• shipped in: wet ice
• Storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP7(4316)

Description

General description

Matrix metallopeptidase 7 (MMP-7) is also known as matrilysin and expressed in tumor cells. It possesses many α-helices and β-sheets, with an active domain. The gene is localized on human chromosome 11q21-q22.

Specificity

Reacts with reduced and non-reduced MMP-7.

Immunogen

synthetic peptide corresponding to the N-terminal end of the catalytic zinc site of human matrix metalloproteinase-7 (matrilysin, PUMP).

Application

Anti-matrix metalloproteinase-7, N-terminal of catalytic zinc site antibody produced in rabbit has been used in immunohistochemistry and Western blotting.[1]

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Matrix metallopeptidase 7 (MMP-7) is a proteolytic enzyme which acts on fibronectin, laminin and collagen type IV. It can also activate other metalloproteinases like MMP-2 and MMP-9. MMP-7 plays an important role in the growth of cancerous cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids