M2567
Melanin Concentrating Hormone (6-17)
≥97% (HPLC), synthetic, lyophilized powder
Synonym(s):
MCH
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About This Item
Empirical Formula (Hill Notation):
C67H104N22O14S3
Molecular Weight:
1537.88
MDL number:
UNSPSC Code:
51111800
Recommended Products
biological source
synthetic
Quality Level
sterility
non-sterile
assay
≥97% (HPLC)
form
lyophilized powder
composition
Peptide content, ≥70%
solubility
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PMCH(5367)
Amino Acid Sequence
Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp [Disulfide bridge: 7-16]
General description
Melanin Concentrating Hormone (MCH) is a 19 amino acid cyclic neuropeptide. It belongs to a group of orexigenic peptides. MCH is abundantly expressed in the hypothalamus.
Application
Melanin Concentrating Hormone has been used as a hepta-decapeptide to study its effects on the reproductive axis and follicular development in female Oreochromis mossambicus.
Biochem/physiol Actions
Melanin Concentrating Hormone (MCH) functions in regulating feeding and energy homeostasis. It also plays a role in modulating arousal, promoting motivated behaviors, sleep patterns, and reproductive physiology. MCH is involved in controlling rapid eye movement (REM) sleep in rats. It acts as a nonselective agonist of melanin-concentrating hormone receptors 1 and 2 (MCHR-1 and -2).
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1)
Febs Letters null
G J Hervieu et al.
The European journal of neuroscience, 12(4), 1194-1216 (2000-04-13)
Melanin-concentrating hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. It is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key messenger in the regulation of
The role of melanin concentrating hormone (MCH) in the central chemoreflex: a knockdown study by siRNA in the lateral hypothalamus in rats.
Li N
PLoS ONE (2014)
Melanin-concentrating hormone facilitates migration of preadipocytes.
Cook LB
Molecular and Cellular Endocrinology (2010)
Genetic tests of biologic systems in affective disorders
E Hattori
Molecular Psychiatry (2005)
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