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L8039

Sigma-Aldrich

Lipoprotein, high density from human plasma

≥95% (SDS-PAGE), solution

Synonym(s):

α-Lipoprotein, HDL, High density lipoprotein

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About This Item

CAS Number:
308068-14-6
MDL number:
MFCD00164407
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

human plasma

Quality Level

200

assay

≥95% (SDS-PAGE)

form

solution

packaging

vial of 10 mg protein

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P02649
P02655
P04114

functional group

ester
phospholipid

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... APOB(338) , APOC2(344) , APOE(348)

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Biochem/physiol Actions

High density lipoprotein (HDL) serves as the transit agent for cholesterol away from blood, tissues, and organs of the body to the liver, where cholesterol breakdown occurs. This process ultimately helps to remove cholesterol from the arteries. Colloquially known as the "good cholesterol", HDL makes up 20%-30% of the total cholesterol in the body.

HDL is used in cardiovascular research and the development of potential therapeutic approaches to cardiovascular risk management.

Physical form

Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4.

Other Notes

View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Kyung-Hyun Cho
Medicines (Basel, Switzerland), 8(7) (2021-08-07)
The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I
Mark J Cziraky et al.
Journal of managed care pharmacy : JMCP, 14(8 Suppl), S3-28 (2009-11-07)
Most clinicians recognize the importance of reducing low-density lipoprotein cholesterol (LDL-C) and, therefore, address this therapeutic need to decrease cardiovascular disease risk. In addition to the critical role that LDL-C plays, recent studies have shown the contribution of other lipid
Santiago Redondo et al.
Lipids in health and disease, 10, 175-175 (2011-10-12)
Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and
Tisha R Joy
Pharmacology & therapeutics, 135(1), 18-30 (2012-04-03)
Reduction in low-density lipoprotein cholesterol (LDL-C) levels has been associated with a 25-30% reduction in cardiovascular disease risk. However, there still remains a significant and quantifiable risk. Since epidemiologic data have demonstrated that low levels of high-density lipoprotein cholesterol (HDL-C)
Joseph B Dubé et al.
Current opinion in lipidology, 23(2), 133-140 (2012-02-14)
Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). Recent large-scale meta-analyses have confirmed elevated Lp(a) concentrations to
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Articles

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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