K1513

Kendomycin from Streptomyces violaceoruber

solid

• Synonym(s): (−)-TAN 2162
• Empirical Formula (Hill Notation): C₂₉H₄₂O₆
• CAS Number: 183202-73-5
• Molecular Weight: 486.64
• MDL number: MFCD00076711
• UNSPSC Code: 12352202
• PubChem Substance ID: 24896208
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 200
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; neoplastics
• mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(C)C(O)=O
• InChI: 1S/C32H61N13O9/c1-15(2)13-19(33)25(48)42-21(10-8-12-39-32(36)37)27(50)43-20(9-7-11-38-31(34)35)26(49)40-17(5)24(47)44-22(14-46)28(51)45-23(16(3)4)29(52)41-18(6)30(53)54/h15-23,46H,7-14,33H2,1-6H3,(H,40,49)(H,41,52)(H,42,48)(H,43,50)(H,44,47)(H,45,51)(H,53,54)(H4,34,35,38)(H4,36,37,39)
• InChI key: PPBZOEOSJVJLRX-UHFFFAOYSA-N

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Potent endothelin receptor antagonist. Antiosteoporotic compound. Shows also remarkable antibacterial and cytotoxic activity. A putative cellular target for cytotoxicity has been identified: inhibition or altered regulation of the proteasome.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)