I6904

Anti-Inositol Hexakisphosphate Kinase antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-IP6 Kinase
• MDL number: MFCD03096967
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 50 kDa
• species reactivity: mouse, rabbit, rat, human
• technique(s): western blot: suitable
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... IHPK1(9807) , IHPK2(51447) , IHPK3(117283) ; mouse ... Ihpk1(27399) , Ihpk2(76500) , Ihpk3(271424) ; rat ... Ihpk1(50560) , Ihpk2(59268)

Description

General description

The gene IP6K1 (inositol hexakisphosphate kinase 1), also referred to as IHPK1, is mapped to human chromosome 3p21.31. The 1323bp open reading frame contains six exons that encode a protein of 441 amino acids. It is found to be expressed in several tissues, such as testis, brain, heart, pancreas, liver, kidney, and skeletal muscle.

Immunogen

synthetic peptide corresponding to amino acids 216-233 of human IP6 kinase.

Biochem/physiol Actions

The gene IP6K1 (inositol hexakisphosphate kinase 1) encodes a member of the inositol hexakisphosphate kinases (InsP6K) that also comprise of InsP6K2, and InsP6K3. The members of this family are involved in the conversion of InsP6 (phytic acid) to InsP7 (diphosphoinositol-pentakisphosphate), which functions in vesicular trafficking and exocytosis, apoptosis, and insulin disposition. Knock-out of this gene in mice has been shown to increase insulin sensitivity due to a decrease in the levels of InsP7, a physiologic inhibitor of Akt, a serine/threonine protein kinase that regulates glucose homeostasis. IP6K1 is found to negatively regulate PtdIns(3,4,5)P3 signaling, which in turn, regulates the function of neutrophils in innate immunity.

Physical form

100 μg of affinity isolated IgG in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids