I2033
Anti-phospho-Insulin Receptor/Insulin-Like Growth Factor-1 Receptor (pTyr1158/1162/1163) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IR/IGF1R
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 0.1-1.0 mg/mL using stimulated CHO-T cells
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IGF1R(3480)
General description
Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. IGF 1R is fully activated by phosphorylation of tyrosine residues at Tyr1158, Tyr1162 and Tyr1163. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1R signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-phospho-IR/IGF1R (pTyr1158/1162/1163) specifically recognizes human receptor and insulin-like growth factor-1 receptor phosphorylated at tyrosines 1158, 1162 and 1163. It may cross react with mouse and rat IR/IGF1R (100% homology).
Anti-phospho-IR/IGF1R (pTyr1158/1162/1163) specifically recognizes human receptor and insulin-like growth factor-1 receptor phosphorylated at tyrosines 1158, 1162 and 1163. It may cross react with mouse and rat IR/IGF1R (100% homology).
Immunogen
synthetic phosphopeptide derived from the region of IR that contains tyrosines 1158, 1162, and 1163.
Application
Anti-phospho-IR/IGF1R (pTyr1158/1162/1163) antibody may be used for immunoblotting at a working concentration of 0.1-1.0 μg/ml using whole cell lysates from CHO-T cells.
Physical form
Solution in Dulbecco′s phosphate buffered saline, pH 7.3, containing 50% glycerol, 1 mg/mL BSA (IgG and protease-free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Lysophosphatidylcholine inhibits insulin-induced akt activation through protein kinase C-α in vascular smooth muscle cells
Motley ED et al
Hypertension, 3, 508-512 (2002)
Rosaria Ottanà et al.
Molecules (Basel, Switzerland), 26(2) (2021-01-14)
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chronic complications. Multiple ligands
Rosanna Maccari et al.
European journal of medicinal chemistry, 252, 115270-115270 (2023-03-20)
Type 2 diabetes mellitus (T2DM) is a serious chronic disease with an alarmingly growing worldwide prevalence. Current treatment of T2DM mainly relies on drug combinations in order to control blood glucose levels and consequently prevent the onset of hyperglycaemia-related complications.
H Yu et al.
Journal of the National Cancer Institute, 91(2), 151-156 (1999-01-29)
Insulin-like growth factors (IGFs), in particular IGF-I and IGF-II, strongly stimulate the proliferation of a variety of cancer cells, including those from lung cancer. To examine the possible causal role of IGFs in lung cancer development, we compared plasma levels
J M Chan et al.
Science (New York, N.Y.), 279(5350), 563-566 (1998-02-07)
Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases
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