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Key Documents

H3786

Sigma-Aldrich

3′-p-Hydroxypaclitaxel

95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C47H51NO15
CAS Number:
132160-32-8
Molecular Weight:
869.91
MDL number:
MFCD03457859
UNSPSC Code:
12161501

Quality Level

100

assay

95% (HPLC)

form

solid

storage temp.

−20°C

InChI

1S/C47H51NO15/c1-24-31(61-43(57)36(53)35(27-17-19-30(51)20-18-27)48-41(55)28-13-9-7-10-14-28)22-47(58)40(62-42(56)29-15-11-8-12-16-29)38-45(6,32(52)21-33-46(38,23-59-33)63-26(3)50)39(54)37(60-25(2)49)34(24)44(47,4)5/h7-20,31-33,35-38,40,51-53,58H,21-23H2,1-6H3,(H,48,55)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key

XKSMHFPSILYEIA-MZXODVADSA-N

Application

Used for determining CYP3A4 activity.

Physical form

Each vial contains 20 nmoles (± 1%) (approx. 17.4 μg).

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCC0730
MKBW1198V
MKBV4527V
MKBR9385V
MKBS0473V

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Heleen A Bardelmeijer et al.
Anti-cancer drugs, 14(3), 203-209 (2003-03-14)
Previous mass balance studies in humans and mice have shown that the fecal and urinary recovery of paclitaxel and known metabolites (3' -hydroxypaclitaxel, 6alpha-hydroxypaclitaxel and 3',6alpha-dihydroxypaclitaxel) was not complete. Obviously this discrepancy is caused by the existence of other yet
M T Huizing et al.
Journal of chromatography. B, Biomedical applications, 674(2), 261-268 (1995-12-15)
A reversed-phase high-performance liquid chromatographic (HPLC) method has been validated for the quantitative determination of the three major paclitaxel metabolites (6 alpha-hydroxypaclitaxel, 3'-p-hydroxypaclitaxel, 6 alpha,3'-p-dihydroxypaclitaxel) in human plasma. The HPLC system consists of an APEX-octyl analytical column and acetonitrile-methanol-0.02 M
Wei Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(22), 2018-2022 (2011-06-28)
A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the determination of paclitaxel (Taxol) and its two major metabolites in human plasma has been developed. Samples were prepared after liquid-liquid extraction and analyzed on a C(18) column interfaced
Ryoko Taniguchi et al.
Journal of pharmacological sciences, 97(1), 83-90 (2005-01-19)
Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown that genetic
Hiroaki Yamaguchi et al.
Biomedical chromatography : BMC, 27(4), 539-544 (2012-09-29)
A column-switching liquid chromatography/electrospray ionization tandem mass spectrometry to determine paclitaxel and its metabolites, 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma was developed. The analytical system had a Shim-Pack MAYI-ODS (10 × 4.6 mm i.d.) trapping column with deproteinization ability that concentrates analytes and
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