H1635

N-Hippuryl-His-Leu hydrate

chromogenic, ≥98% (HPLC), powder

• Synonym(s): N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate
• Empirical Formula (Hill Notation): C₂₁H₂₇N₅O₅ · xH₂O
• CAS Number: 207386-83-2
• Molecular Weight: 429.47 (anhydrous basis)
• Beilstein/REAXYS Number: 5664178
• EC Number: 250-597-9
• MDL number: MFCD00149318
• UNSPSC Code: 12352204
• PubChem Substance ID: 24895469
• NACRES: NA.32

Properties

• product name: N-Hippuryl-His-Leu hydrate, powder, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: acetic acid: ~50 mg/mL
• storage temp.: −20°C
• SMILES string: O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O
• InChI: 1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1
• InChI key: NWOJMNXIJBZMPK-QJHJCNPRSA-N
• Gene Information: human ... ACE(1636) , ACE2(59272) ; mouse ... ACE3(217246) ; rat ... ACE(11421) , ACE2(70008) , ACE3(498012)

Description

Amino Acid Sequence

NBz-Gly-His-Leu

Application

N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates, semimembranosus muscle samples, and rabbit lung acetone powder.

Biochem/physiol Actions

N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).

Substrates

Substrate for angiotensin converting enzyme.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)