Immunogen Sequence: GI # 20336203, sequence 1248-1332
Recombinant ataxia telangiectasia mutated protein isoform 1
Application
Anti-ATM antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in DNA damage response (DDR). It can be active in the absence of DDR and in response to oxidative stress in mitochondria. ATM induces signaling and initiation of cell cycle checkpoint signaling in response to DNA-damaging agents, such as ionizing radiation. It may be associated with pancreatic cancers. ATM inhibition is found to induce mimosine-arrested cells to enter S phase and is associated with preventation of replication fork stalling-induced DNA damage.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ataxia-telangiectasia mutated (ATM) is a Ser/Thr protein kinase that plays a critical role in DNA damage-induced signaling and initiation of cell cycle checkpoint signaling in response to DNA-damaging agents such as ionizing radiation. We have previously reported the ATM protein
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(7), 1865-1872 (2014-02-04)
To determine how often loss of ataxia-telangiectasia-mutated (ATM) protein expression occurs in primary pancreatic ductal adenocarcinomas and to determine its prognostic significance. The expression of ATM and TP53 was determined by immunohistochemistry in 397 surgically resected pancreatic ductal adenocarcinomas (Hopkins;
The Journal of biological chemistry, 289(9), 5730-5746 (2014-01-15)
Mimosine is an effective cell synchronization reagent used for arresting cells in late G1 phase. However, the mechanism underlying mimosine-induced G1 cell cycle arrest remains unclear. Using highly synchronous cell populations, we show here that mimosine blocks S phase entry
Biochemical and biophysical research communications, 443(4), 1286-1290 (2014-01-11)
Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in DNA damage response (DDR). A recent study reported that oxidized ATM can be active in the absence of DDR. However, the issue of where ATM is
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