ATM
ataxia telangiectasia mutated
Synonyms:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Species:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Thale Cress ATM (823975), Zebrafish atm (403064), chicken ATM (395401), dog ATM (479450), domestic cat ATM (101089291), Horse ATM (100061765), cow ATM (526824) ...More
UniProtKB ID:
Gene ID:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- Zebrafish(403064) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- naked mole-rat(101718948) ataxia telangiectasia mutated
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Androgen Receptor (C-term) antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP224, affinity isolated antibody,
Species Reactivity
human, mouse, pig
Application
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-p-ATM (Ser1981) Antibody, clone 1E19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Anti-ATM Antibody, clone AM9, ascites fluid, clone AM9, Upstate®,
Species Reactivity
human
Application
western blot
Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12, Alexa Fluor™ 488, clone 10H11.E12, from mouse, ALEXA FLUOR™ 488,
Species Reactivity
human, mouse
Application
immunocytochemistry
Monoclonal Anti-ATM antibody produced in mouse, clone 2C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunofluorescence
Proteins
Product Number
Description
Species