Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

GW21062

Sigma-Aldrich

Anti-CD221 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IGFIR, Anti-Insulin-like growth factor 1 receptor

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD00282340
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21062

technique(s)

western blot: suitable

NCBI accession no.

NP_000866.1

UniProt accession no.

O43467

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IGF1R(3480)

Immunogen

Immunogen Sequence: GI # 4557665, sequence 214-318
Recombinant insulin-like growth factor 1 receptor

Application

Anti-CD221 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The insulin-like growth factor 1 (IGF-1) receptor is a protein on human cell surface. It activates mitotic division and inhibits apoptosis of cancer cells. IGF-1R may play an important role in tumor growth and metastasis through lymphatic pathway. It may act as a biomarker in non-small cell lung cancer (NSCLC) and may be useful in customized chemotherapy. IGF1R inhibitor may constitute an attractive modality for treating endometrial cancer. Mutations in the gene lead to abnormal functioning of IGF-I receptors. It has also been reported that mutated CD221 may retard intrauterine and subsequent growth in humans.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
049K1804
029K1748
029K1713

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

M Gryko et al.
Polish journal of pathology : official journal of the Polish Society of Pathologists, 65(2), 135-140 (2014-08-15)
Most patients with gastric cancer are diagnosed at advanced clinical stages with a high frequency of lymph node metastasis. It is very important to find novel factors for the early diagnostic and prognostic evaluation of gastric cancer. It has been
Ilan Bruchim et al.
Cancer letters, 352(2), 214-219 (2014-07-06)
The present study evaluated the cytotoxic activity of methyl jasmonate (MJ) in endometrial cancer cells and examined the hypothesis that the apoptotic and anti-proliferative actions of MJ in these cell lines can be enhanced by co-targeting the insulin-like growth factor-1
Yuki Kawashima et al.
The Journal of clinical endocrinology and metabolism, 90(8), 4679-4687 (2005-06-02)
Mouse knockout models have clearly demonstrated the critical importance of IGF-I and IGF receptor type 1 (IGF-IR) for embryonic growth as well as postnatal growth. We hypothesized that mutations of IGF-IR gene might predispose to short stature in children born
Adam Vilmar et al.
Anticancer research, 34(6), 2991-2996 (2014-06-13)
The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase
Mio Nakanishi et al.
Cell, 177(4), 910-924 (2019-04-16)
The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of this assemblance is unknown. Here, we identify human pluripotent founder cells (hPFCs) that initiate, as well as

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service