F7803
Anti-phospho-Focal Adhesion Kinase (pSer732) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-phospho-FAK (pSer732)
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 125 kDa
species reactivity
mouse, human
technique(s)
flow cytometry: suitable
immunoblotting: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PTK2(5747)
mouse ... Ptk2(14083)
rat ... Ptk2(25614)
General description
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of
integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase
transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site
binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion.
integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase
transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site
binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion.
Specificity
Also reacts with FAK-Related Non-Kinase (FRNK).
Immunogen
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human FAK that contains serine 732. The sequence is conserved in mouse, rat and chicken.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, containing 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
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Yoshiaki V Nishimura et al.
Development (Cambridge, England), 141(18), 3540-3550 (2014-09-04)
Neuronal migration is crucial for development of the mammalian-specific six-layered cerebral cortex. Migrating neurons are known to exhibit distinct features; they form a cytoplasmic dilation, a structure specific to migrating neurons, at the proximal region of the leading process, followed
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