NLR family CARD domain-containing protein 4 is a protein encoded by NLRC4 gene in humans. NLRC4 is also known as CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CARD12 and CLR2. It is a member of the Ced4/ Apaf-1 family.
Immunogen
peptide corresponding to the N-terminus of the human CLAN protein, both A and B isoforms.
Application
Anti-CLAN Protein (CARD12) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000 using human lung lysates.
Biochem/physiol Actions
CLAN (CARD12) induces apoptosis and plays a critical role in NF-κB signaling pathways. CARD12 plays an important role during activation of caspase-1 and is dependent on the nucleotide-binding site. It prevents motor-neuron apoptosis induced by a variety of signals.
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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Biochemical and biophysical research communications, 284(1), 77-82 (2001-05-26)
The CED4/Apaf-1 family of proteins functions as critical regulators of apoptosis and NF-kappaB signaling pathways. A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells. CARD12 is most similar in structure to
Biochemical and biophysical research communications, 331(4), 1114-1119 (2005-05-11)
CARD12 (Ipaf/Clan) is an important regulator of caspase-1 activation. It belongs to the family of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins. The NBS domain of the NBS-LRR proteins contains putative ATP/GTPase-specific P-loop and Mg2+-binding site motifs. However, the
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