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0.1 MG
$683.90
About This Item
Empirical Formula (Hill Notation):
C217H360N68O60S10
CAS Number:
Molecular Weight:
5202.25
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28
$683.90
List Price$977.00Save 30%Web-Only Promotion
Available to ship onApril 30, 2025Details
Request a Bulk Order
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Quality Level
assay
≥90% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Gene Information
human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)
Amino Acid Sequence
Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala [Disulfide bridge: 4-20, 12-25, 19-36, 27-34]
General description
Application
Biochem/physiol Actions
Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).[1]
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
Features and Benefits
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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New CACNA1A deletions are associated to migraine phenotypes
Grieco GS, et al.
The Journal of Headache and Pain, 19(1), 75-75 (2018)
I M Mintz et al.
Nature, 355(6363), 827-829 (1992-02-27)
Voltage-dependent calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cell death. Many types of calcium channels exist in mammalian brains, but high-affinity blockers are
I M Mintz et al.
Neuron, 9(1), 85-95 (1992-07-01)
The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety of central and peripheral neurons. omega-Aga-IVA blocked a substantial
T J Turner et al.
Science (New York, N.Y.), 258(5080), 310-313 (1992-10-09)
Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too small to probe with electrodes, and available pharmacological tools such as dihydropyridines and omega-conotoxin are
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura
Terwindt G M, et al.
Neurology, 56(8), 1028-1032 (2001)
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