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About This Item
Empirical Formula (Hill Notation):
C120H182N38O43S6
CAS Number:
Molecular Weight:
3037.35
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
Quality Level
assay
≥97% (HPLC)
form
powder
composition
Peptide content, ~70%
storage temp.
−20°C
Gene Information
human ... CACNA1B(774)
mouse ... CACNA1B(12287)
rat ... CACNA1B(257648)
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Amino Acid Sequence
Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]
Application
ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.
Powerful probe for exploring the vertebrate pre-synaptic terminal.
Biochem/physiol Actions
ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.
Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Precursor structure of omega-conotoxin GVIA determined from a cDNA clone
Colledge CJ, et al.
Toxicon, 30(9), 1111-1116 (1992)
Inhibition of central neurotransmitter release by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel
Dooley DJ, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 336(4), 467-470 (1987)
V A Eterović et al.
Brain research, 772(1-2), 191-202 (1997-12-24)
The effect of spermine (Spm) and of omega-conotoxin GVIA (CTX) on the population excitatory postsynaptic potentials (pEPSP) in stratum radiatum of the CA1 area were compared. CTX decreased irreversibly the initial slope of pEPSP by 57%. Spm produced a maximum
Structure-function relationships of $\omega$-conotoxin GVIA Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues
Lew MJ, et al.
The Journal of Biological Chemistry, 272(18), 12014-12023 (1997)
Cristina Pozzoli et al.
Current protocols in toxicology, Chapter 21, Unit 21-Unit 21 (2012-11-22)
The protocol detailed in this unit is designed to assess intestinal peristaltic motility in the isolated small intestine in vitro and to measure the effects of drugs able to interfere with gut propulsive activity. The procedure is based on Trendelenburg's
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