A5336
Asparaginase−polyethylene glycol from Escherichia coli
lyophilized powder, ~70 units/mg protein
Synonym(s):
PEG-Asparaginase
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About This Item
MDL number:
UNSPSC Code:
12352204
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form
lyophilized powder
specific activity
~70 units/mg protein
extent of labeling
≥40 mol PEG per mol protein
storage temp.
−20°C
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Physical form
Contains PEG plus 5% citrate buffer salts
Preparation Note
Asparaginase coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Abuchowski et al.
Cancer biochemistry biophysics, 7(2), 175-186 (1984-06-01)
The covalent attachment of monomethoxypolyethylene glycol (PEG) to asparaginases from Escherichia coli and Vibrio succinogenes by new coupling methodology produced conjugates that are active, stable, without significant immune response, and with greatly extended plasma half-lives in mice. Therapeutic efficacies were
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