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biological source
bovine thyroid
form
lyophilized powder
mol wt
~670 kDa
Mr ~660000
concentration
~0.6% iodine
technique(s)
bioconjugation: suitable
solubility
H2O: 20 mg/mL, hazy, yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... TG(280706)
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Application
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Biochem/physiol Actions
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A B Rawitch et al.
The Journal of biological chemistry, 258(4), 2079-2082 (1983-02-25)
A 19-residue, thyroxine (T4)-containing peptide, Tryp-T4, has been isolated from the tryptic digest of a low molecular weight, iodine-enriched fragment derived from 19S bovine thyroglobulin. This tryptic peptide represents the only site of significant iodination in the parent polypeptide fragment.
L Mercken et al.
Nature, 316(6029), 647-651 (1985-08-15)
In mammals, an adequate supply of thyroid hormones is essential for normal growth and neurological development. The biosynthesis of thyroid hormones involves an iodinated precursor protein, thyroglobulin, which may be considered an extreme example of a pro-hormone. Thyroglobulin is a
Kouame Adou et al.
Analytical chemistry, 81(24), 10186-10192 (2009-11-21)
A charge reduction (CR) interface for electrospray ionization that permits simultaneous analysis of nanoparticle solutions by multiple detection methods was characterized. In the direct infusion configuration, a constant flow of analyte solution undergoes electrospray ionization (ESI). The charged aerosol is
Chowdhury F Miah et al.
Surgery, 156(6), 1491-1496 (2014-12-03)
The American Thyroid Association recommends lymph node mapping (LNM) ultrasonography 6-12 months after thyroidectomy for patients with papillary thyroid cancer (PTC). The yield of LNM over thyroglobulin (TG) screening is not well defined. We sought to investigate this relationship. Post
F Latrofa et al.
Clinical and experimental immunology, 178(3), 438-446 (2014-08-20)
The subclass distribution of thyroglobulin autoantibodies (TgAb) is debated, whereas their epitope pattern is restricted. Radioidine ((131)I) treatment for Graves' disease (GD) induces a rise in TgAb levels, but it is unknown whether it modifies subclass distribution and epitope pattern
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