Vanylglycol is also known as MHPG or MOPEG and can be biosynthesized from 3,4-dihydroxyphenylglycol and guaiacol. MHPG is a O-methylated metabolite of normetanephrine. Alcohol consumption increases the level of Vanylglycol in urine and CSF. Vanylglycol is found normally in urine, in plasma and cerebrospinal fluid. Outside of the human body, vanylglycol has been detected, but not quantified in several different foods such as blackcurrants, chinese bayberries, elderberries, oriental wheats, and poppies. This could make vanylglycol a potential biomarker for the consumption of these foods. Vanylglycol has been found to be associated with several diseases such as multi-infarct dementia, epilepsy, hereditary spastic paraplegia, and schizophrenia; also vanylglycol has been linked to the inborn metabolic disorders including aromatic l-amino acid decarboxylase deficiency.
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