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917648

Sigma-Aldrich

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C12H18ClNO
CAS Number:
Molecular Weight:
227.73
MDL number:
UNSPSC Code:
12352200

Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

hydroxyl

storage temp.

2-8°C

SMILES string

OCC1=CC=C(C2CCNCC2)C=C1.Cl

InChI

1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H

InChI key

JSCRYCUDRVBGRN-UHFFFAOYSA-N

Application

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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