916587

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid

≥95%

• Synonym(s): Semi-flexible linker for PROTAC^® development
• Empirical Formula (Hill Notation): C₁₇H₂₃NO₄
• CAS Number: 828243-30-7
• Molecular Weight: 305.37
• MDL number: MFCD02178898
• UNSPSC Code: 12352106

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: Boc; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(OC(C)(C)C)N1CCC(C2=CC(C(O)=O)=CC=C2)CC1
• InChI: 1S/C17H23NO4/c1-17(2,3)22-16(21)18-9-7-12(8-10-18)13-5-4-6-14(11-13)15(19)20/h4-6,11-12H,7-10H2,1-3H3,(H,19,20)
• InChI key: PDPYHAXCPUSEMT-UHFFFAOYSA-N

Description

Application

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H315,H317,H319,H410
• pcodes: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable