90061
4-Deoxy-D-erythronic acid sodium salt hydrate
≥97.0% (GC)
Synonym(s):
(2R,3R)-2,3-Dihydroxybutyric acid sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C4H8O4 · xNa+ · yH2O
Molecular Weight:
120.10 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.24
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Quality Level
assay
≥97.0% (GC)
optical activity
[α]/D -10±2°, c = 0.5 in 0.1 M NaOH
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Biochem/physiol Actions
4-Deoxyerythronic acid has been associated with uremia and diabetes mellitus type 1, but is also a normal organic acid present in human biofluids, derived presumably from L-threonine.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_c
Not applicable
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F W Bultitude et al.
Clinical chemistry, 21(9), 1329-1334 (1975-08-01)
We describe a method for comparing plasma samples from healthy subjects and from chronic uremic patients before and after dialysis. It was used to determine the nature of those metabolites that appear to characterize the uremic state. Preliminary fractionation of
Konstantinos A Kouremenos et al.
Journal of chromatography. A, 1217(1), 104-111 (2009-11-10)
Comprehensive two-dimensional gas chromatography (GCxGC) time-of-flight mass spectrometry (ToFMS) was applied to the analysis of urinary organic acids from patients with inborn errors of metabolism. Abnormal profiles were obtained from all five patients studied. Methylmalonic academia and deficiencies of 3-methylcrotonyl-CoA
Sílvia O Diaz et al.
Journal of proteome research, 12(2), 969-979 (2012-12-13)
In this work, untargeted NMR metabonomics was employed to evaluate the effects of pregnancy on the metabolite composition of maternal urine, thus establishing a control excretory trajectory for healthy pregnancies. Urine was collected for independent groups of healthy nonpregnant and
D B Kassel et al.
Biomedical & environmental mass spectrometry, 13(10), 535-540 (1986-10-01)
Metabolic profiling of urinary organic acids from patients with juvenile-onset (Type 1) diabetes mellitus have revealed significantly elevated levels of 2-hydroxybutyric and 4-deoxythreonic acids. To test the hypothesis that these metabolites, as well as 4-deoxyerythronic acid, are derived from L-threonine
Yi Zhang et al.
Molecular cell, 73(6), 1127-1137 (2019-02-18)
We have previously proposed that selective inheritance, the limited transmission of damaging mtDNA mutations from mother to offspring, is based on replication competition in Drosophila melanogaster. This model, which stems from our observation that wild-type mitochondria propagate much more vigorously
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