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N-Methyl-N-trimethylsilylacetamide

derivatization grade (GC derivatization), LiChropur™, ≥97.0% (GC)

Synonym(s):

MSA

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About This Item

Empirical Formula (Hill Notation):
C6H15NOSi
CAS Number:
7449-74-3
Molecular Weight:
145.27
Beilstein/REAXYS Number:
506975
EC Number:
231-217-0
MDL number:
MFCD00040758
UNSPSC Code:
23151816
PubChem Substance ID:
329761691
NACRES:
NA.22

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥97.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.439

bp

159-161 °C (lit.)

density

0.904 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

CN(C(C)=O)[Si](C)(C)C

InChI

1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3

InChI key

QHUOBLDKFGCVCG-UHFFFAOYSA-N

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General description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).[1]

Application

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:       
  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.[2]       
  • Characterization of damaged products of thymine[3] and cytosine[4] formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Other Notes

Powerful silylating agent for polar compounds[5][6]

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

118.4 °F - closed cup

flash_point_c

48.0 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB7757

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Methanesulfonic acid ≥99.0%

Sigma-Aldrich

471356

Methanesulfonic acid

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