Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

69480

Supelco

N-Methyl-N-trimethylsilylacetamide

for GC derivatization, LiChropur™, ≥97.0% (GC)

Synonym(s):

MSA

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C6H15NOSi
CAS Number:
7449-74-3
Molecular Weight:
145.27
Beilstein/REAXYS Number:
506975
EC Number:
231-217-0
MDL number:
MFCD00040758
UNSPSC Code:
12000000
PubChem Substance ID:
329761691
NACRES:
NA.22

grade

derivatization grade ((GC derivatization))
for GC derivatization

Quality Level

100

assay

≥97.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.439

bp

159-161 °C (lit.)

density

0.904 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

CN(C(C)=O)[Si](C)(C)C

InChI

1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3

InChI key

QHUOBLDKFGCVCG-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).[1]

Application

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:       
  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.[2]       
  • Characterization of damaged products of thymine[3] and cytosine[4] formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Other Notes

Powerful silylating agent for polar compounds[5][6]

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

118.4 °F - closed cup

flash_point_c

48.0 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCB7757

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Methanesulfonic acid ≥99.0%

Sigma-Aldrich

471356

Methanesulfonic acid

Jesse Elias et al.
PLoS medicine, 15(5), e1002562-e1002562 (2018-05-02)
Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip
Sample derivatization in separation science
Analytical separation science (2015)
Damaged products of thymine in hydroxyl radical solution under UV irradiation
Hong J, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 63(1), 109-118 (1999)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
M. Donike
Journal of Chromatography A, 103, 91-91 (1975)
View All Related Papers

Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service