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67653

Supelco

L-Kynurenine

analytical standard

Synonym(s):

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O3
CAS Number:
2922-83-0
Molecular Weight:
208.21
MDL number:
MFCD00069912
UNSPSC Code:
41116107

grade

analytical standard

assay

≥98% (HPLC)

optical activity

[α]25/D -32.5 to -28.0°, c = 0.4 in H2O

shelf life

limited shelf life, expiry date on the label

impurities

≤5.0% water

application(s)

clinical testing

format

neat

SMILES string

N[C@@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1

InChI key

YGPSJZOEDVAXAB-QMMMGPOBSA-N

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Biochem/physiol Actions

Key intermediate in the breakdown pathway of tryptophan.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0725
BCCF5434
BCCF1185
BCCC9792
BCBZ4751

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Xue Jiang et al.
International journal of immunopathology and pharmacology, 34, 2058738420950584-2058738420950584 (2020-09-24)
Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A

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