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02569

Sigma-Aldrich

Lipase from Candida antarctica

lyophilized, powder, beige, ~0.3 U/mg

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About This Item

CAS Number:
9001-62-1
EC Number:
3.1.1.3 (BRENDA, IUBMB)
EC Number:
232-619-9
MDL number:
MFCD00131509
UNSPSC Code:
12352204
NACRES:
NA.26

biological source

fungus (Candida antartica)

form

powder

quality

lyophilized

specific activity

~0.3 U/mg

color

beige

storage temp.

2-8°C

InChI

1S/C11H9N3O2.Na/c15-8-4-5-9(10(16)7-8)13-14-11-3-1-2-6-12-11;/h1-7,16H,(H,12,14);/q;+1/b13-9-;

InChI key

QWZUIMCIEOCSJF-CHHCPSLASA-N

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General description

Lipase, a versatile enzyme is found in animals, plants, and various microorganisms. It is considered as nature′s catalysts and is stable.[1] C. antarctica lipase A (CALA) and C. antarctica lipase B (CALB) are the two types of lipases produced by Candida antarctica. CALA is a thermostable protein, that is mostly stable at acidic pH. CALB is stable at alkaline pH. CALA and CALB are extremely stable in their immobilized state and can be employed at high temperatures for long hours without losing their activity.[2]

Biochem/physiol Actions

Lipases are capable of hydrolyzing fats into fatty acids and glycerols at the water-lipid interface and can reverse the activity in non-aqueous conditions. Microbial lipases are mostly used in various industrial or commercial applications.[1] CALA may be particularly useful for the conversion of heavily branched substrates. CALA has a distinct activity for sterically hindered alcohols, especially tertiary alcohols. CALB possesses a wide range of substrate specificity, both in terms of regio- and enantioselectivity.[2]

Unit Definition

1 U corresponds to the amount of enzyme which liberates 1 μmol oleic acid per minute at pH 8.0 and 40 °C (triolein, Cat. No. 62314 as substrate)

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
063458/1

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Naveen Patel et al.
Recent patents on biotechnology, 13(1), 45-56 (2018-10-30)
Background and Sources: Lipase enzyme is a naturally occurring enzyme found in the stomach and pancreatic juice. Its function is to digest fats and lipids, helping to maintain correct gallbladder function. Lipase is the one such widely used and versatile
Lipases from candida a ntarctica: unique biocatalysts from a unique origin
Kirk O and Christensen MW
Organic Process Research & Development, 6(4), 446-451 (2002)
How high-density lipoprotein fuels the failing heart.
Nina Schlueter et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 955-957 (2013-03-06)
First report of telaprevir-induced pancreatitis.
Carlos Ventura et al.
Digestive diseases and sciences, 58(3), 887-888 (2013-02-09)
Leah E Ross et al.
Biochimica et biophysica acta, 1831(6), 1052-1059 (2013-03-09)
The adsorption of colipase is essential for pancreatic triglyceride lipase activity and efficient dietary fat digestion. Yet, little is known about which specific amino acids in the hydrophobic surface of colipase influence adsorption. In this study, we systematically substituted alanine
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