The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
Cell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target Aβ₄₂ production
Product does not compete with ATP.
Reversible: no
Target IC50: 1.8 µM against Aβ42 production
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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