344931-M

Furin Inhibitor II

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Furin Inhibitor II, Hexa-D-arginine, H-(D)RRRRRR-NH₂
• Empirical Formula (Hill Notation): C₃₆H₇₅N₂₅O₆
• Molecular Weight: 954.14
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL; DMSO: soluble
• storage temp.: −20°C

Description

General description

A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.

A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.

Biochem/physiol Actions

Primary Target
furin

Target K_i: 106 nM against Furin

Warning

Toxicity: Standard Handling (A)

Sequence

H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable