203701
bpV(HOpic)
A potent phosphotyrosine phosphatase inhibitor.
Synonym(s):
bpV(HOpic), Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
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About This Item
Linear Formula:
K2[VO(O2)2C6H4NO3] · 4H2O
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥70% (51V-NMR)
form
solid
potency
14 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
water: 4 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
PTEN
PTEN
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Unstable in solution; reconstitute just prior to use.
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Zeinab Ghezelayagh et al.
Journal of assisted reproduction and genetics, 39(8), 1739-1747 (2022-07-13)
The effect of PTEN inhibitor (Bpv(HOpic); Bpv) and mTOR activators (phosphatidic acid (PA) and propranolol (PP)), were evaluated on the activation and subsequent development of human primordial follicles in ovarian tissue culture. Slow frozen-thawed human ovarian cortical strips were incubated
Amit Kumar et al.
Molecular and cellular biology, 44(7), 261-272 (2024-06-03)
The protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1) plays an important role in modulating glucose and lipid homeostasis. We previously suggested a potential role of SHP-1 in the regulation of peroxisome proliferator-activated receptor γ2 (PPARγ2) expression and
Cyrine Ben Dhaou et al.
Angiogenesis (2021-09-16)
Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here
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