810230P
Avanti
C6-NBD Safingol
Avanti Research™ - A Croda Brand 810230P, powder
Synonym(s):
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-L-threo-sphinganine
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C30H51N5O6
CAS Number:
Molecular Weight:
577.76
UNSPSC Code:
12352211
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (810230P-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810230P
shipped in
dry ice
storage temp.
−20°C
General description
Safingol belongs to the lysosphingolipid class and is the synthetic L-threo-stereoisomer of (D-erythro-) sphinganine.
Biochem/physiol Actions
Safingol, a competitive inhibitor of sphingosine kinase 1, exhibits anticancer activity. It is known to increase antitumor activity of cisplatin in xenograft experiments.
Packaging
5 mL Amber Glass Screw Cap Vial (810230P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jesse Coward et al.
Autophagy, 5(2), 184-193 (2008-12-23)
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange
Mark A Dickson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(8), 2484-2492 (2011-01-25)
Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S)
Synthesis of threo-beta-aminoalcohols from aminoaldehydes via chelation-controlled additions. Total synthesis of l-threo sphingosine and safingol
Jung ME and Yi SW
Tetrahedron Letters, 53(32), 4216-4220 (2012)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service