Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

View All Documentation

700029P

Avanti

3β,7β-dihydroxy-5-cholestenoic acid

Avanti Research™ - A Croda Brand

Synonym(s):

(25R)-cholest-5-en-26-oic acid, 3β,7β-hydroxy

Sign Into View Organizational & Contract Pricing

Select a Size

All Photos(2)

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C27H44O4
CAS Number:
1246298-66-7
Molecular Weight:
432.64
MDL number:
MFCD22416723
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700029P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) is associated with plasma and is a C27 acid.[1] 3β,7β-diHCA is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) by the action of the enzyme hydroxysteroid 11-β dehydrogenase 1.[2]

Application

3β,7β-dihydroxy-5-cholestenoic acid may be used as an authentic diastereoisomer standard in mass spectrometry (MS) experiments.[3]

Biochem/physiol Actions

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) levels are elevated in Niemann-Pick type C (NPC) disease and Niemann-Pick (NP) disease type B disorders.[1] It elicits toxicity to oculomotor neurons.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (700029P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sterolomics in biology, biochemistry, medicine
Griffiths WJ and Wang Y
TrAC, Trends in Analytical Chemistry, 115280-115280 (2018)
Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers
Griffiths WJ, et al.
Chemistry and Physics of Lipids, 207, 69-80 (2017)
Metabolism of non-enzymatically derived oxysterols: clues from sterol metabolic disorders
Griffiths WJ, et al.
Free Radical Biology & Medicine, 144, 124-133 (2019)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service