T54801

2,2,2-Trichloroethanol

ReagentPlus^®, ≥99%

• Synonym(s): Trichloroethyl alcohol
• Linear Formula: Cl₃CCH₂OH
• CAS Number: 115-20-8
• Molecular Weight: 149.40
• Beilstein/REAXYS Number: 1697495
• EC Number: 204-071-0
• MDL number: MFCD00004677
• UNSPSC Code: 12352100
• PubChem Substance ID: 24900284
• NACRES: NA.22

Properties

• vapor density: 5.16 (vs air)
• Quality Level: 200
• vapor pressure: 1 mmHg ( 20 °C)
• product line: ReagentPlus^®
• assay: ≥99%
• refractive index: n20/D 1.49 (lit.)
• bp: 152-154 °C (lit.)
• mp: 17.8 °C (lit.)
• density: 1.56 g/mL at 20 °C (lit.)
• SMILES string: OCC(Cl)(Cl)Cl
• InChI: 1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2
• InChI key: KPWDGTGXUYRARH-UHFFFAOYSA-N

Description

Application

The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:

• Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
• Preparation of TCE ester of chlorosulfuric acid.
• Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318,H336
• pcodes: P261 - P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 230.0 °F - closed cup
• flash_point_c: 110 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter