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1193265

USP

Diethylene glycol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

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About This Item

Linear Formula:
(HOCH2CH2)2O
CAS Number:
111-46-6
Molecular Weight:
106.12
Beilstein/REAXYS Number:
969209
MDL number:
MFCD00002882
UNSPSC Code:
41116107
PubChem Substance ID:
329749578
NACRES:
NA.24

vapor density

2.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

API family

diethylene glycol

autoignition temp.

442 °F

expl. lim.

2-12.3 %

manufacturer/tradename

USP

refractive index

n20/D 1.447 (lit.)

bp

245 °C (lit.)

mp

−10 °C (lit.)

density

1.118 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diethylene glycol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Propylene Glycol
  • Glycerin
  • Polyoxyl 40 Hydrogenated Castor Oil
  • Sorbitol Solution
  • Polyethylene Glycol 3350
  • Maltitol Solution
  • Noncrystallizing Sorbitol Solution

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

280.4 °F - closed cup

flash_point_c

138 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glycerin
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 28(4), 2123-2123 (2020)
Polyethylene Glycol 3350
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(4), 3584-3584 (2020)
Propylene Glycol
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 33(2), 3753-3753 (2020)
Nestor R Sosa et al.
Annals of emergency medicine, 64(1), 38-47 (2014-01-21)
Diethylene glycol is a toxic industrial solvent responsible for more than 13 mass poisonings since 1937. Little is known about the clinical spectrum, progression, and neurotoxic potential of diethylene glycol-associated disease because of its high mortality and the absence of
Joshua G Schier et al.
Journal of public health policy, 30(2), 127-143 (2009-07-15)
Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports
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