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901960

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Cellulose-Alginate bioink

suitable for 3D bioprinting applications

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.23

form

viscous liquid

impurities

<25 EU/mL Endotoxin

color

white

pH

6.5-7

density

1.050 g/mL

application(s)

3D bioprinting

storage temp.

2-8°C

General description

3D bioprinting is the printing of biocompatible materials, cells, growth factors, and the other supporting materials necessary to yield functional complex living tissues. 3D bioprinting has been used to generate several different types of tissue such as skin, bone, vascular grafts, and cartilage structures. Based upon the desired properties, different materials and formulations can be used to generate both hard and soft tissues. While several 3D printing methods exist, due to the sensitivity of the materials used, extrusion-based methods with bioinks are most commonly employed.

Material comes prepackaged in syringe with 5ml of product.

Application

Cellulose-Alginate bioink, a biocompatible polymer, can be used as a hydrogel for 3D printing in tissue engineering applications. It can be used in the fabrication of nanofibrillar suture coatings due to its cell viability and suturing performance.[1][2][3][4]
Due to its low cost, biocompatibility, and facile gelation, alginate is one of the most common components of commercial bioinks.[5] Alginate is a naturally-occurring polysaccharide, obtained from the cell walls of brown algae, that is composed of guluronic and mannuronic acid. While alginate forms hydrogels under mild conditions, nanocellulose is added in this formulation to improve printability and final structure properties.[6] Cellulose-Alginate acellular bioink is provided as a ready-to-print, low endotoxin, and aseptic formulation in 5 mL syringes.

Legal Information

Product of Cellink

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH0499

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Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems
Lauren P, et al.
PLoS ONE, 12(8), e0183487-e0183487 (2017)
Rheological studies on nanocrystalline cellulose/alginate suspensions
Junior EAP, et al.
Journal of Molecular Liquids, 277(8), 418-423 (2019)
A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation
Wei J, et al.
Carbohydrate Polymers, 238, 116207-116207 (2020)
Nanocellulosic materials as bioinks for 3D bioprinting
Piras CC, et al.
Biomaterials Science, 5(10), 1988-1992 (2017)
Carmen C Piras et al.
Biomaterials science, 5(10), 1988-1992 (2017-08-23)
3D bioprinting is a new developing technology with lots of promise in tissue engineering and regenerative medicine. Being biocompatible, biodegradable, renewable and cost-effective, cellulosic nanomaterials have recently captured the attention of researchers due to their applicability as inks for 3D
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Three-Dimensional Bioprinting for Tissue and Disease Modeling

Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.

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