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A1112

Sigma-Aldrich

Alginic acid sodium salt from brown algae

low viscosity

Synonym(s):

Algin, Sodium alginate

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About This Item

CAS Number:
9005-38-3
MDL number:
MFCD00081310
UNSPSC Code:
12352201
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

algae (brown)

Quality Level

200

form

powder

color

white to brown

viscosity

4-12 cP, 1 % in H2O(25 °C)

solubility

water: 10 mg/mL, cloudy to hazy, faintly yellow

storage temp.

2-8°C

SMILES string

[Na+].[O-]C(=O)C1O[C@H]([C@H]([C@H]([C@@H]1O)O)O)O

InChI

1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1/t1-,2-,3-,4?,6+;/m0./s1

InChI key

MSXHSNHNTORCAW-MPGIDXPLSA-M

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Application

Acid hydrolysates of alginic acid can be used to prepare a-1,4-~-Polyguluronic and B- 1,4-~-Polymannuronic acids [1]
Alginate, a colloidal polyuronic acid structural molecule capable of gelation, is used in the preparation of colloidal biodegradable structures such as gels, biofilms, beads, nanoparticles, and microcapsules suitable for applications that range from gel based separation technologies to drug delivery and cell preservation.

Other Notes

A straight-chain, hydrophilic, colloidal, polyuronic acid composed of guluronic and mannuronic acid residues.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000311178
0000380418
0000380419
0000372949
0000372947

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E E Farmer et al.
The Journal of biological chemistry, 266(5), 3140-3145 (1991-02-15)
The in vitro phosphorylation by [gamma-32P]ATP of a 34-kDa plasma membrane-associated protein (pp34) from tomato and potato is strongly enhanced in the presence of alpha-1,4-D-polygalacturonic acid (PGA) fragments (Farmer, E. E., Pearce, G., and Ryan, C. A. (1989) Proc. Natl.
Juan Du et al.
The Plant cell, 32(11), 3576-3597 (2020-09-05)
Pectins are abundant in the cell walls of dicotyledonous plants, but how they interact with other wall polymers and influence wall integrity and cell growth has remained mysterious. Here, we verified that QUASIMODO2 (QUA2) is a pectin methyltransferase and determined
Jordan Gulli et al.
Biotechnology progress, 36(1), e2925-e2925 (2019-10-07)
Encapsulated microbes have been used for decades to produce commodities ranging from methyl ketone to beer. Encapsulated cells undergo limited replication, which enables them to more efficiently convert substrate to product than planktonic cells and which contributes to their stress
Daeha Joung et al.
Advanced functional materials, 28(39) (2018-09-26)
A bioengineered spinal cord is fabricated via extrusion-based multi-material 3D bioprinting, in which clusters of induced pluripotent stem cell (iPSC)-derived spinal neuronal progenitor cells (sNPCs) and oligodendrocyte progenitor cells (OPCs) are placed in precise positions within 3D printed biocompatible scaffolds
Julie Vanacker et al.
Fertility and sterility, 99(5), 1363-1368 (2013-02-05)
To evaluate the survival and growth potential of human preantral follicles isolated before and after cryopreservation. Pilot study. Gynecology research unit in a university hospital. Six women aged 27 to 32 years. Six ovarian biopsy samples were cut into two
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Questions

1–10 of 11 Questions  

  1. What is the carboxylic acid content of this polymer ?

    1 answer

    1. The carboxylic acid content is not determined for this product.

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  4. What is the ratio of mannuronic acid to guluronic acid in product A1112, Alginic acid sodium salt?

    1 answer

    1. This product is not tested on a lot by lot basis for MG ratio. However, historical data indicates that this material is 60-70 % Mannuronic acid and 30-40 % Guluronic acid resulting in an M/G ratio of 1.56. The degree of polymerization is 400-600. Molecular weight: approx. 30 000 - 100 000.

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  5. WHAT IS THE PURITY OF THE PRODUCT NO. A1112? Can you provide the NMR spectra of this product?

    1 answer

    1. The purity of this product is not a determined. An NMR of the material has not been performed. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a sample or lot-specific Certificate of Analysis:
      https://www.sigmaaldrich.com/product/sigma/a1112#product-documentation

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  6. What is the endotoxin level of this product?

    1 answer

    1. This product is not currently tested for endotoxin. Please see the link below to review the specification sheet and the tests performed on this product: https://www.sigmaaldrich.com/specification-sheets/805/253/A1112-BULK________SIGMA____.pdf

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  7. What taxa of brown algae are used for this product?

    1 answer

    1. This product is extracted from a seaweed from Norway. Further taxonomic classification is not determined.

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  8. Does this product create a low or high stiffness gel?

    1 answer

    1. This product is not tested for gelation or gel strength. Alginate forms a gel in the presence of cations. Typically CaCl2 is used to initiate gel formation. Increasing the concentration of calcium will result in a more firm gel. Calcium chloride may be added at a range of 0.1M to 0.5M, with gel strength increasing with the CaCl2 concentration.

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  9. Which is the maximum solubility in water of the alginate?

    1 answer

    1. Per our specifications, we test solubility in water at 10 mg/ml. We do not test the maximum amount that can be dissolved. When used as a gelling agent for plant tissue culture, Alginic acid is prepared at 1.75 – 4.0 % (w/v) in a low calcium buffered medium. At these concentrations, following stirring, the alginate will completely dissolve yielding a clear solution. It can then be filter sterilized or autoclaved. Gelation occurs in the presence of cations - typically CaCl2.

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  10. What is the percentage of guluronic, mannuronic monomers?

    1 answer

    1. The percentage of guluronic and mannuronic monomers are not determined for this product.

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1–10 of 11 Questions  

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