542741

5-Bromothiophene-2-sulfonamide

97%

• Empirical Formula (Hill Notation): C₄H₄BrNO₂S₂
• CAS Number: 53595-65-6
• Molecular Weight: 242.11
• MDL number: MFCD00067990
• UNSPSC Code: 12352100
• PubChem Substance ID: 24878630
• NACRES: NA.22

Properties

• assay: 97%
• mp: 138-142 °C (lit.)
• SMILES string: NS(=O)(=O)c1ccc(Br)s1
• InChI: 1S/C4H4BrNO2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H,(H2,6,7,8)
• Inchi Key: WXJQQLDICAOBJB-UHFFFAOYSA-N

Description

General description

5-Bromothiophene-2-sulfonamide can be synthesized by reacting 5-bromothiophene-2-sulfonyl fluoride with ammonium hydroxide in 2-methyltetrahydrofuran.[1]

Application

5-Bromothiophene-2-sulfonamide may be used to synthesize:

• 5-(phenylthio)thiophene-2-sulfonamide[2]
• 5-bromothiophene-2-sulfonyl acetamide[3]
• 5-arylthiophene-2-sulfonylacetamide derivatives[4]

It may also be used in the preparation of the following 5-arylthiophene-2-sulfonamides:[3]

• 5-phenylthiophene-2-sulfonamide
• 5-(3-cyno-5-(trifluoromethyl)phenyl)thiophene-2-sulfonamide
• 5-(3,5-bis(trifluoromethyl)phenyl)thiophene-2-sulfonamide
• 5′-chloro-2,2′-bithiophene-5-sulfonamide
• 5′-methyl-2,2′-bithiophene-5-sulfonamide
• 5-p-tolylthiophene-2-sulfonamide
• 5-(4-methoxyphenyl)thiophene-2-sulfonamide
• 5-(4-chlorophenyl)thiophene-2-sulfonamide
• 5-(3,4-dichlorophenyl)thiophene-2-sulfonamide
• 5-(3,5-dimethylphenyl)thiophene-2-sulfonamide
• 5-(4-chloro-3-fluorophenyl)thiophene-2-sulfonamide

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)