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199338

Sigma-Aldrich

1,4-Diamino-2-butanone dihydrochloride

99%

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About This Item

Linear Formula:
H2NCH2CH2COCH2NH2 · 2HCl
CAS Number:
3660-09-1
Molecular Weight:
175.06
EC Number:
222-914-0
MDL number:
MFCD00012908
UNSPSC Code:
12352100
PubChem Substance ID:
24851907
NACRES:
NA.22

assay

99%

mp

221 °C (dec.) (lit.)

functional group

amine
ketone

SMILES string

Cl[H].Cl[H].NCCC(=O)CN

InChI

1S/C4H10N2O.2ClH/c5-2-1-4(7)3-6;;/h1-3,5-6H2;2*1H

InChI key

HDRKYQXFDHZZOW-UHFFFAOYSA-N

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Application

1,4-Diamino-2-butanone dihydrochloride was used as a media supplement for the growth of B.pertussis and B. bronchiseptica[1].

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
12411JG
07909MB
05210JQ

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T J Brickman et al.
Journal of bacteriology, 178(1), 54-60 (1996-01-01)
Chromosomal insertions defining Bordetella bronchiseptica siderophore phenotypic complementation group III mutants BRM3 and BRM5 were found to reside approximately 200 to 300 bp apart by restriction mapping of cloned genomic regions associated with the insertion markers. DNA hybridization analysis using
D Guzmán-de-Peña et al.
Fungal genetics and biology : FG & B, 21(2), 198-205 (1997-04-01)
Regulation of aflatoxin biosynthesis during differentiation of Aspergillus parasiticus was analyzed by using a drug that inhibits the development of the fungus and mutants affected in sporulation. Diaminobutanone, a competitive inhibitor of ornithine decarboxylase, repressed spore germination. If added after
D Menezes et al.
Parasitology research, 98(2), 99-105 (2005-11-12)
Trypanosoma cruzi is the etiological agent of American trypanosomiasis. Most of the available data on trypanosomatid parasites were obtained from African trypanosomes. Parasitic protozoa polyamine metabolism and transport pathways comprise valuable targets for chemotherapy. T. cruzi cannot synthesize putrescine, but
D Guzmán-de-Peña et al.
Antonie van Leeuwenhoek, 73(2), 199-205 (1998-08-26)
We analyzed the regulation of sterigmatocystin biosynthesis in wild type and mutant strains of Emericella nidulans (= Aspergillus nidulans). A positive correlation between both asexual and sexual sporulation and synthesis of the mycotoxin was observed. Those conditions which favored sporulation
Chrislaine O Soares et al.
Free radical biology & medicine, 50(12), 1760-1770 (2011-04-07)
The α-aminoketone 1,4-diamino-2-butanone (DAB), a putrescine analogue, is highly toxic to various microorganisms, including Trypanosoma cruzi. However, little is known about the molecular mechanisms underlying DAB's cytotoxic properties. We report here that DAB (pK(a) 7.5 and 9.5) undergoes aerobic oxidation
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