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199338

Sigma-Aldrich

1,4-Diamino-2-butanone dihydrochloride

99%

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About This Item

Linear Formula:
H2NCH2CH2COCH2NH2 · 2HCl
CAS Number:
3660-09-1
Molecular Weight:
175.06
EC Number:
222-914-0
MDL number:
MFCD00012908
UNSPSC Code:
12352100
PubChem Substance ID:
24851907
NACRES:
NA.22

assay

99%

mp

221 °C (dec.) (lit.)

functional group

amine
ketone

SMILES string

Cl[H].Cl[H].NCCC(=O)CN

InChI

1S/C4H10N2O.2ClH/c5-2-1-4(7)3-6;;/h1-3,5-6H2;2*1H

InChI key

HDRKYQXFDHZZOW-UHFFFAOYSA-N

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Application

1,4-Diamino-2-butanone dihydrochloride was used as a media supplement for the growth of B.pertussis and B. bronchiseptica[1].

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
12411JG
07909MB
05210JQ

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Marcos A Vannier-Santos et al.
Microbiology (Reading, England), 154(Pt 10), 3104-3111 (2008-10-04)
Polyamines are important regulators of growth and differentiation in a variety of cells, including parasitic protozoa. Promastigotes of Leishmania species have high levels of putrescine and spermidine and their growth can be inhibited by polyamine biosynthesis antagonists. The putrescine analogue
Georgina E Reyna-López et al.
Current microbiology, 48(2), 118-123 (2004-04-02)
We utilized our modification of the amplified fragment length polymorphism technique for the determination of changes occurring in the DNA methylation patterns during the dimorphic transition of the fungi Mucor rouxii, Yarrowia lipolytica, and Ustilago maydis. To determine the specificity
C Maia et al.
Parasitology research, 103(2), 363-370 (2008-04-26)
The protozoan Giardia lamblia is the most frequent intestinal parasite of first-world countries and a major cause of waterborne disorder often referred to as traveler's diarrhea. We have previously noticed that the putrescine analog 1,4-diamino-2-butanone (DAB) remarkably inhibits the growth
C Cano et al.
Journal of bacteriology, 170(12), 5946-5948 (1988-12-01)
DNA from intact or spherically growing spores of Mucor rouxii is highly methylated, whereas DNA from germlings has low levels of methylation. DNA from spores incubated with hydroxyurea or 1,4-diaminobutanone is also highly methylated. The reversal of the effect of
M Martinez-Pacheco et al.
Archives of microbiology, 151(1), 10-14 (1989-01-01)
Diamino butanone (DAB), a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon. Addition of DAB
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