142077

2,2,2-Trichloroethyl chloroformate

98%

• Synonym(s): 2,2,2-Trichloroethoxycarbonyl chloride
• Linear Formula: ClCOOCH₂CCl₃
• CAS Number: 17341-93-4
• Molecular Weight: 211.86
• Beilstein/REAXYS Number: 970619
• EC Number: 241-363-7
• MDL number: MFCD00000810
• UNSPSC Code: 12352100
• PubChem Substance ID: 24848380
• NACRES: NA.22

Properties

• vapor pressure: 0.06 psi ( 20 °C)
• assay: 98%
• form: liquid
• refractive index: n20/D 1.471 (lit.)
• bp: 171-172 °C (lit.)
• density: 1.539 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: ClC(=O)OCC(Cl)(Cl)Cl
• InChI: 1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2
• InChI key: LJCZNYWLQZZIOS-UHFFFAOYSA-N

Description

General description

2,2,2-Trichloroethyl chloroformate (TrocCl) serves as a versatile reagent used for selective acylation and dealkylation in organic synthesis. It is used in regio, chemo, and stereoselective synthesis.

Application

• 2,2,2-Trichloroethyl chloroformate was used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples.
• It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
• It was used as reagent during N-demethylation of dextromethorphan.
• It was used as protecting reagent for aliphatic and aromatic hydroxyl and amino groups.

Protecting reagent for aliphatic and aromatic hydroxyl and amino groups.

Safety Information

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H314,H331
• pcodes: P280 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Inhalation - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter