Anti-PPAR-α antibody detects endogenous levels of total PPAR-α protein.
The PPAR-α (peroxisome proliferator-activated receptor α) gene is mapped to human chromosome 22q13.31. Ppar-α is localized to the nucleus.
Immunogen
The antiserum was produced against synthesized peptide derived from human PPAR-alpha.
Immunogen Range: 6-55
Biochem/physiol Actions
PPAR-α (peroxisome proliferator-activated receptor α) is a receptor transcription factor that inhibits inflammation, by preventing the nuclear factor κB activation. Omega-3 long-chain polyunsaturated fatty acids is known to be the ligand that brings out the anti-inflammatory action of Ppar-α. Ppar-α is involved in epidermal proliferation and differentiation and therefore serves as a skin barrier. PPARα mediates lipid metabolism by inducing fatty acid oxidation and also regulates glucose metabolism. Variation in the gene is observed in schizophrenia.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Frontiers in cardiovascular medicine, 9, 834199-834199 (2022-07-06)
Peripheral atherosclerosis that accumulates in the extracranial carotid and lower extremity arteries can lead to significant morbidity and mortality. However, atherosclerotic disease progression is often not homogenous and is accelerated by diabetes. We previously observed increased phospholipid content in minimally
Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Jung Y
Biochemical and Biophysical Research Communications, 493(1), 220-226 (2017)
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