B6311
BTO-1
≥98% (HPLC), solid
Synonym(s):
5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide
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About This Item
Empirical Formula (Hill Notation):
C9H4N4O4S
CAS Number:
Molecular Weight:
264.22
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
solid
color
tan
solubility
H2O: <2 mL/mL
DMSO: ≥5 mg/mL
storage temp.
2-8°C
SMILES string
NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O
InChI
1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)
InChI key
FKRBAXZAJBBIAJ-UHFFFAOYSA-N
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
Kristin P Leister et al.
Current chemical genomics, 5, 21-29 (2011-06-07)
Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, are not
Mark E Burkard et al.
PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle
Keiko Yata et al.
Molecular cell, 45(3), 371-383 (2012-02-14)
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)
Conrad von Schubert et al.
PLoS biology, 8(9) (2010-10-12)
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host
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